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br Downstream signalling of AKT A consensus phosphorylation
2024-05-07
Downstream signalling of AKT A consensus phosphorylation motif has been described for AKT substrates: R-X-R-X-X-S/T-B where X represents any amino Nepafenac synthesis and B represents bulky hydrophobic residues (Alessi, Caudwell, Andjelkovic, Hemmings, & Cohen, 1996). Numerous AKT substrates have
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DAergic as well as GABAergic and glutamatergic neurons send
2024-05-07
DAergic, as well as GABAergic and glutamatergic neurons, send projections to target forebrain structures, such as the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC), and support diverse functional roles (Carr and Sesack, 2000a, Carr and Sesack, 2000b, Omelchenko and Sesack, 2009, Taylor
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The cellular mechanism underlying the
2024-05-07
The cellular mechanism underlying the CGS12066-mediated inhibition of glutamate release from hippocampal nerve terminals through presynaptic 5-HT1B receptors remains to be elucidated. 5-HT1B receptors are coupled to PTX-sensitive G proteins (Gi or Go) that have been shown to inhibit AC activity as w
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A previous study reported that the serotonergic mechanism wa
2024-05-07
A previous study reported that the serotonergic mechanism was involved in the psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field (Matsumoto et al., 2004). Sumitaka Inoue et al. (Inoue et al., 2014) reported that pretreatment with a 5-HT1A receptor partial
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C34 The enzyme mediated ATP sensing
2024-05-07
The enzyme-mediated ATP-sensing mechanism in zebrafish can be compared with previous studies in other animal species reporting that enzymatic conversion of chemicals in the peripheral olfactory organ results in either “activation” or “inactivation” of odorants and pheromones. In male silkmoth, the a
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Our published data showed that
2024-05-07
Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function
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MK-8776 Plant material and growth conditions
2024-05-07
Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark MK-8776 in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant transformation. The c
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br Disclosure br Acknowledgement br Introduction CYP A
2024-05-06
Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal survivin (baculoviral IAP repeat-containing protein 5) (21-28) in male testes and adrenal glands. The 17α-hydr
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br Conclusion br List of abbreviations br Acknowledgment The
2024-05-06
Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S
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Roles of Aurora kinases in
2024-05-06
Roles of Aurora kinases in directly activating multiple oncogenic pathways and promoting proliferation as well as transformation have also been demonstrated. Aurora-A has been shown to up-regulate telomerase reverse transcriptase mRNA through c-myc [26]. The kinase was also implicated in activating
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The MOB and AOB are important in
2024-05-06
The MOB and AOB are important in ungulates (Keller and Levy, 2012, Sanchez-Andrade and Kendrick, 2009), which rely heavily on odorant information for social interactions (Baum and Cherry, 2015, Keller and Levy, 2012, Osada et al., 2014, Villagran and Ungerfeld, 2013). The release of GABA and glutama
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br Materials and methods br Results br
2024-05-06
Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o
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Although apelin g kg shows negative early
2024-05-06
Although apelin 60μg/kg shows negative (early) and positive (late) inotropic effects, since ERK1/2 phosphorylation starts at the min 5 of administration [6], ERK1/2 phosphorylation mediate positive inotropic effects of apelin 60μg/kg. After the simultaneous inhibition of KOR and APJ the phosphoryla
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br Future view and implications The selection
2024-05-06
Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi
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Among all the polysaccharide derivatives cationic
2024-05-06
Among all the polysaccharide derivatives, cationic carbohydrate polymers such as quaternary ammonium salts and quaternary phosphonium salts have been the most popular and most efficient target gnrh antagonist in medical applications [24] and water treatment [25]. Recently, quaternary phosphonium sa