• With the present study we aim

  2018-11-07

  

  With the present study we aim to clarify the trajectory of short-term recognition memory and sensorimotor gating throughout the complete period of adolescence, including pubertal time points, in male rats. In male rats a peripubertal period can be defined from ∼pd 38, shortly before the physiologica

• br Conclusions br Acknowledgements The authors would like

  2018-11-07

  

  Conclusions Acknowledgements The authors would like to thank Danielle Dellarco, Alexa Hubbard, Natasha Mehta, Gloria Pedersen, and Theresa Teslovich Woo for their help in recruiting and testing participants. We thank the l-alanine who participated in this study. This work was supported by the

• ras gtpase br Case history This previously healthy year old

  2018-11-06

  

  Case history This previously healthy 23-year-old male patient presented with an absence seizure for the first time on November 9, 2009. On examination, he was conscious and alert, and all vital signs were normal. The cranial nerves were intact. Muscle power was 5/5 in four limbs. Sensation was no

• Another important issue is how to

  2018-11-06

  

  Another important issue is how to sling the reconstructed lower lip to prevent sialorrhea. With this in mind, many suspension techniques have been proposed for lower lip reconstruction. These techniques can be categorized as static or dynamic procedures. Methods of static suspension include use of m

• Treatment options for CAF include surgery and catheter

  2018-11-06

  

  Treatment options for CAF include surgery and catheter closure. Swan et al reported the first successful closure of a fistula from using a cardiopulmonary bypass. Surgery is not free of risk but associated with low morbidity and mortality rates ranging from 0% to 1.4%. Myocardial infarction occurs i

• The latest imaging technologies have played a major

  2018-11-06

  

  The latest imaging technologies have played a major role in determining Cryptosporidium\'s structural relationship with the gregarines but also how they share important similarities in their host parasite relationships (Clode et al., 2015; Koh et al., 2013, 2014). Most recently, Cryptosporidium has

• UNC 0642 br Experimental Procedures br Acknowledgments br

  2018-11-06

  

  Experimental Procedures Acknowledgments Introduction Imaging of optically sectioned nuclei provides an unprecedented opportunity to observe the details of fate specification, tissue patterning, and morphogenetic events at single-cell resolution in space and time. Imaging is now recognized a

• Current standard therapy for glioblastoma

  2018-11-06

  

  Current standard therapy for glioblastoma consists of debulking surgery followed by radiation with concomitant and adjuvant administration of the alkylating agent temozolomide (Stupp et al., 2009). Most studies investigating intrinsic GSC resistance have focused on the role of DNA damage responses a

• In the current study we investigated the effects

  2018-11-06

  

  In the current study, we investigated the effects of Ptp4a3 loss on the tumor-initiating cell population of colon tumors from wildtype (WT) or Ptp4a3-knockout (KO) mice using an in vitro culture system previously used to study human metastatic colon cancer stem abscisic acid (Odoux et al., 2008). T

• Using this approach we showed that the ReNcell VM

  2018-11-06

  

  Using this approach we showed that the ReNcell VM cell line can be cultivated in 3D microarray alginate spots, and preserve its proliferative progenitor state during on-chip expansion, albeit with lower proliferation rates and viabilities than those observed in conventional 2D culture platforms. Add

• Nodal Activin signaling is an evolutionarily conserved signa

  2018-11-06

  

  Nodal/Activin signaling is an evolutionarily conserved signal transduction pathway, and plays critical roles in the maintenance and differentiation of hESCs. Nodal and Activin (Activin A and Activin B [Thompson et al., 2004]) are members of the transforming growth factor beta (TGFβ) superfamily, and

• In Part I of this paper I will introduce

  2018-11-06

  

  In Part I of this paper I will introduce four central challenges to the organization of international stem cell trials that emerge from this high level of regulatory variation. These obstacles apply in principle to all innovative multi-country stem cell trials that are subject to approval by a drug

• SB202190 cost The following are the supplementary data relat

  2018-11-06

  

  The following are the supplementary data related to this article. Conflict of interest Acknowledgments We thank Dr. Carrie Shemanko (University of Calgary) for providing the HC11 cells. We thank Dr. Min Fu, Confocal Core Facility, McGill University Health Centre, for the assistance and techni

• br Materials and methods br Acknowledgments Research culmina

  2018-11-06

  

  Materials and methods Acknowledgments Research culminating in the derivation of this line was funded by a grant (PM07321) from Scottish Enterprise Economic Development Agency to PDS, MB, and AC. Resource table Resource details Human ESC culture and processing was performed in a grade A

• We show that the GCase defect was associated with

  2018-11-05

  

  We show that the GCase defect was associated with impaired autophagosome formation in the N370S GBA1 mutation dopaminergic haNCSCs, in agreement with Schondorf et al. (2014). We have shown that ambroxol rescues the biochemical abnormalities resulting from the N370S mutation. Ambroxol increased GCase

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