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MK-1775 br Methods br Results A total of cases including
2019-04-23

Methods Results A total of 2136 cases, including 614 controls, and 707 LAA, 375 SVO, and 440 HICH cases, were enrolled in this study. Clinical parameters between the control individuals and patients with different stroke subtypes are listed in Table 1. The average age and serum HDL-C level wer
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Similar to HF myocardial infarction MI is followed
2019-04-22

Similar to HF, myocardial infarction (MI) is followed by significant down-regulation of multiple K currents in the peri-infarct zone. These changes may contribute to after-depolarization and ventricular arrhythmia in MI ventricles. However, none of the previous studies reported MI in an increased IK
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br Conclusion br Conflicts of interest br Acknowledgments br
2019-04-22

Conclusion Conflicts of interest Acknowledgments Case report A 56-year-old woman with prior history of dual-chamber permanent pacemaker (PPM) implantation (ELA Medical Symphony DR 2550, ELA Medical, Montrouge, France) for symptomatic complete notch pathway block presented to the Cardiac
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It is noteworthy that in a recent study Le
2019-04-22

It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex
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br Discussion Valproic acid is a potent inhibitor of
2019-04-22

Discussion Valproic procollagen c proteinase is a potent inhibitor of histone deacetylases (HDAC). It can modify the structure of chromatin allowing recruitment of transcription factors to restore epigenetically suppressed genes. Valproic acid has been shown to possess antiproliferative activity
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Chronic immunosuppression has been reported to be
2019-04-22

Chronic immunosuppression has been reported to be linked with PEL [11]. Several patients with concomitant PEL and HIV infection were reported. Thus, a small portion of the elderly with immunosuppressive conditions may have a tendency to develop MALT lymphoma. Our elderly patient had no HIV infection
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br At least people were killed and
2019-04-22

At least 69 people were killed and eight others were missing after a landslide in Shenzhen, north of Hong Kong, on Dec 20, 2015. Unlike most landslides triggered by high-intensity rainfall or earthquakes, this CA-074 Me disaster was man-made and triggered by the collapse of a construction waste d
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6 his tag Supplier The care or intervention provided
2019-04-22

The care or intervention provided during the ED stay for critically ill patients significantly impacts the progression of hospital outcomes. Svenson and colleagues reported that 6 his tag Supplier critically ill patients received critical care procedures commonly performed in the ED while waiting f
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Findings Final data analysis included households nine
2019-04-20

Findings Final data analysis included 28 households: nine from the Tulip filter group, 10 from Waterguard chlorination, and nine from the group who boiled water. Two households had incomplete data and were excluded from analysis. Before the intervention, 29 of 30 households were not treating their w
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ahr inhibitor br Commentary The concept of entrainment mappi
2019-04-20

Commentary The concept of entrainment mapping for ablation of VT is that targeting the site will interrupt the reentrant VT circuit. This site must be located, not only within the circuit, but also in a protected and relatively narrow isthmus. During entrainment mapping, the QRS morphology, S-QR
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p38 inhibitors The tumor microenvironment is enriched
2019-04-20

The tumor microenvironment is enriched with EMVs that are derived not only by proliferating tumor cells, but also from infiltrating macrophages and neutrophils, and support tumor cell survival, growth, invasion and metastasis. Tumor derived EMVs also have the potential to modulate surrounding stroma
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The multivariable Cox regression model also showed
2019-04-20

The multivariable Cox regression model also showed that patients who were divorced, separated, or widowed had a significantly worse outcome than patients who were married or single; the mortality rate for Divorced, Separated or Widowed PLB patients was estimated to be 1.4 times that for married pati
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The majority of breast malignancies are hormone responsive
2019-04-20

The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno
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LQT can have numerous clinical
2019-04-20

LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise
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Illicit financial flight is the unrecorded movement
2019-04-20

Illicit financial flight is the unrecorded movement of capital out of a country in contravention of the regulations of that country. The main mechanism used to undertake this is multinational companies shifting their tax liabilities to sister companies located in low tax jurisdictions, also known as
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