• br Experimental Procedures br Author Contributions H

  2020-09-11

  

  Experimental Procedures Author Contributions H.G. and X.-Y.F. conceived and designed the project. H.G., D.V.D., and X.L. performed most of the experiments and analyzed the data. L.X. helped on Mettl8 KO ESC, RIP, and translational study. Y.S. performed FACS analysis. Y.W. helped with cardiomyo

• We recently employed a functional drug screening approach to

  2020-09-11

  

  We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito

• br Materials and methods br

  2020-09-11

  

  Materials and methods Results Discussion Our previous study showed that ERRγ negatively regulates osteoblast differentiation via inhibiting Runx2 transactivity (Jeong et al., 2009). In the present study, we found that ERRγ also induced miR-433 in osteogenic mesenchymal cell lineage C3H10T1/

• The interaction of EPAC with

  2020-09-11

  

  The interaction of EPAC2 with Rim1 has an important role in regulating neurotransmitter release. In addition, a recent EPAC2 knockout mice model study provides evidence that EPAC2 promotes transmitter release by maintaining the readily releasable pool (RRP) at mossy fiber (MF) synapses in the hippo

• DNA replication checkpoint kinases in both yeast

  2020-09-11

  

  DNA replication checkpoint kinases in both yeast and human sn-Glycero-3-phosphocholine upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork

• Instead of introducing extra hardware or

  2020-09-10

  

  Instead of introducing extra hardware or hardware modification, software-based CFC techniques just insert extra checking instructions into the source code of the target program at compile time so as to have the target program do checking jobs itself. Preeminent software-based CFC techniques proposed

• It is interesting that of

  2020-09-10

  

  It is interesting that of the control groups, female TG controls only had significantly higher MB-COMT protein than non-TG male controls (Supplemental Table 9, P = 0.005), while these two groups have almost equal expression of S-COMT protein (8.54- vs. 8.34-fold) and their COMT enzyme activity is al

• Assessment of DNA damage by comet assay and ChEs activity

  2020-09-10

  

  Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worker

• br Conclusion and future perspectives LDL cholesterol loweri

  2020-09-10

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol Thalidomide the efficacy of cholesterol lowering, both, with statins and with ezetimib

• 69 7 Upon assembly of HLA tetramers loaded with either

  2020-09-10

  

  Upon assembly of HLA tetramers loaded with either of the two peptide versions, we could query the T cell repertoires of RA subjects and healthy individuals for the presence of cognate T 69 7 recognizing the respective peptide-HLA complexes. We found no significant difference in frequencies of T cel

• L 006235 PKA signalling in the nucleus was thought to

  2020-09-10

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the L 006235 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and func

• br DDR receptor and MMP expression

  2020-09-10

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrup

• The monomeric oligomeric states of DDR V

  2020-09-10

  

  The monomeric/oligomeric states of DDR2-V5-His and DDR2-Fc were confirmed by Western blotting under reducing and non-reducing conditions. As shown in Fig. 1b, DDR2-V5-His exhibited a relative molecular mass of ~60 kDa under both reducing and non-reducing conditions, consistent with this protein bein

• In conclusion our work provides the preclinical evidence

  2020-09-10

  

  In conclusion, our work provides the preclinical evidence showing the potent in vivo efficacy of AT7519 on chemoresistant cancer btz calculator synthesis and its underlying mechanisms of action. Our work supports the biological rationale behind the clinical trials initiated with AT7519, particularl

• The enzyme cyclooxygenase COX or prostaglandin endoperoxide

  2020-09-10

  

  The enzyme cyclooxygenase (COX) or prostaglandin endoperoxide H synthase (PGHS) is the key enzyme in the conversion of arachidonic WIN 18446 (AA) into prostaglandins (PGs) [1]. In 1991, researchers found that there were two isoforms of this enzyme called COX-1 and COX-2 with independent genes and d

11464 records 477/765 page Previous Next First page 上5页 476477478479480 下5页 Last page