• While the apparent complexity of

  2022-03-25

  

  While the apparent complexity of gap junction regulation presents challenges, new technologies continue to propel the field forward. Advances in microscopy are increasingly able to capture rapid dynamics at the plasma membrane (e.g., biosensors [67] and lattice light sheet microscopy [100]) and to d

• Following an endoproteolytic cleavage of C secretase trims t

  2022-03-25

  

  Following an endoproteolytic cleavage of C99, γ-secretase trims the remaining fragment Aβ49 or Aβ48 in successive, mostly three-residue steps. Aβ49 typically gives rise to Aβ46, Aβ43, and Aβ40; whereas Aβ48 usually yields Aβ45 and Aβ42 [59]. The physical basis for this characteristic cleavage patter

• Ru II complexes have been reported to

  2022-03-25

  

  Ru(II) complexes have been reported to be both duplex and G-quadruplex structure stabilizers, and potent anticancer agents [[11], [12], [13], [14]]. Barton, Norden, as well as Ji groups have provided detailed information about recognition and reactions of classical duplex DNA by Ru complexes [[47],

• br Summary The presented results of the analysis

  2022-03-25

  

  Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste

• TXNIP interacts with various proteins including

  2022-03-25

  

  TXNIP interacts with various proteins, including NLRP3 (Yoshihara et al., 2014, Zhou et al., 2010). Emerging evidence suggests that TXNIP plays a role in ER stress-mediated cell death and in the NLRP3 inflammasome activation step (Abderrazak et al., 2015, Lerner et al., 2012, Oslowski et al., 2012,

• Liposomes that are less than

  2022-03-24

  

  Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by Rifabutin (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even smaller diameters are

• While reduced protein synthesis provides a model to

  2022-03-24

  

  While reduced protein synthesis provides a model to explain the long-term memory defects of kdm5 and kdm5 flies, new translation is not required for short-term memories. The chronic reduction in translation observed in mutant fly strains may, however, lower the levels of proteins necessary for short

• The hyperacetylation of histone proteins by HATs is known

  2022-03-24

  

  The hyperacetylation of histone proteins by HATs is known to be associated with gene activation [51]. In particular, p300, which is a transcription factor having HAT activity, links activators to the transcription machinery at promoters [52]. The p300/CBP complex dynamically regulates hundreds of di

• To efficiently develop bioactive ligands even if the structu

  2022-03-24

  

  To efficiently develop bioactive ligands even if the structural information of the target protein is unknown, we have presented a three-dimensional structural diversity-oriented strategy based on structural properties of a chiral cyclopropane. Our strategy has allowed us to design and synthesize a s

• YAP TAZ nuclear function is also influenced by interaction

  2022-03-24

  

  YAP/TAZ nuclear function is also influenced by interaction with the TEAD family of transcription factors [96, 97, 98, 99, 100, 101]. The RAC1 U-73122 sale exchange factor protein TIAM1 has recently been linked to YAP/TAZ regulation in the nucleus and cytoplasm. Nuclear TIAM1 inhibits YAP/TAZ binding

• Mitochondrial binding by HK prevents mortality

  2022-03-24

  

  Mitochondrial binding by HK prevents mortality by inhibiting pro-apoptotic factor (Bcl-2 family)-mediated opening of the mitochondrial permeability transition pore (mPTP) (Arora and Pedersen, 1988, Calmettes et al., 2016, Kodde et al., 2007, Pedersen et al., 2002, Rosano, 2011, Schindler and Foley,

• br Patients and methods br Results br Discussion The

  2022-03-24

  

  Patients and methods Results Discussion The positivity of serum anti-HBc is the most commonly used marker to confirm the history of HBV infection. Quantification of serum anti-HBc has been explored as a marker of HBV-induced hepatitis and the adaptive immune response against HBV infection a

• The Fe deficiency treatment significantly increased the shoo

  2022-03-24

  

  The Fe-deficiency treatment significantly increased the shoot/root Fe ratios in both WT and transgenic lines (Fig. 5C), which implied that the Fe distribution from root to shoot may be an adaptive mechanism or stress response in tomato plants. Thus, the overexpression of GSNOR had a positive effect

• Finally our work showed that HAART resulted in significant

  2022-03-24

  

  Finally, our work showed that HAART resulted in significant inter-individual variability among DEGs, which reflected the parthenolide in HIV-affected human gene expressions (Fig. 1, Fig. 2, Fig. 3, Fig. 4). These observations also highlighted the importance of determining common as well as personal

• br Material and methods br Results The search for

  2022-03-24

  

  Material and methods Results The search for proteins selectively expressed in pancreatic islet Cathepsin S inhibitor in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorithm e

11462 records 163/765 page Previous Next First page 上5页 161162163164165 下5页 Last page